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Making DNA analysis results useful to producers through the development of EPDs that incorporate genomic and performance information

The next wave of technology available to livestock producers, including beef producers, is genomics. This new technology allows us to estimate genetic merit for existing traits earlier in life; for new traits; and more accurately for traits that we currently evaluate. This project will develop a new approach to beef cattle selection, one that allows […]

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Identification of biomarkers associated with the onset and progression of major metabolic and infectious diseases of transition dairy cows

The overall goal of this research proposal is to identify molecular biomarkers that are associated with the early prediction, diagnosis, and monitoring of major metabolic and infectious diseases of dairy cattle. Dairy cows are commonly afflicted with a variety of debilitating conditions such as mastitis (udder infection), metritis (uterine infection), laminitis, infertility, ketosis, milk fever,

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Characterization of miRNAs and their targets in food animal pathogen infection models for potential use as markers for improvement of food safety

This project seeks to investigate the potential role of non-coding RNAs, including microRNAs (miRNA), in the control of zoonotic infections in pigs (Salmonella) and cattle (E. coli 0157:H7). MicroRNAs have been shown to control several aspects of human/mouse immune responses but have been poorly investigated in livestock immunity. The long-term goal of the project is

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Using reverse vaccinology to identify novel antigens for vaccine development against Mannheimia haemolytica as a model for bacterial agents associated with bovine respiratory disease

Mannheimia haemolytica is an important bacterial pathogen associated with bovine respiratory disease (BRD) in cattle. The economic losses it generates surpass those incurred by all other diseases of cattle combined, arising from production losses, treatment costs and mortalities. The most widely used method to control BRD is antibiotic administration. However, concerns regarding the use of antibiotics

Using reverse vaccinology to identify novel antigens for vaccine development against Mannheimia haemolytica as a model for bacterial agents associated with bovine respiratory disease Read More »

Continuation of the Bioinformatics Support for the Genome Canada ABC programs

The Visual Genomics Centre (VGC) at the University of Calgary has provided bioinformatics support for three Genome Canada Applied Genomics in Bioproducts or Crops (ABC) projects. As the main products of the bioinformatics support, the Centre has developed and hosted four bioinformatics analysis pipelines for these projects, each of which has been used heavily by

Continuation of the Bioinformatics Support for the Genome Canada ABC programs Read More »

Support for a bioinformatics position for the NSERC TRIA Network

Bioinformatics straddles the disciplines of computer science, computational biology, genomics, and molecular biology. Thus, bioinformaticians require a relatively hard to find set of skills to effectively carry out the bioinformatics analyses. Over the past eight years, the TRIA Mountain Pine Beetle project has generated substantial genomic resources and genomic datasets. This project will conduct value-added

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SMarTForest: Spruce marker technologies for sustainable forestry

The SMarTForest project will develop tools to enhance forest health and productivity and to increase the value recovered from forest plantations. This project will leverage the power of genomics to develop diagnostic markers based on DNA, metabolites, and proteins to advance breeding in Canada’s major spruce species. Marker systems are aimed at identifying trees and

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Synthetic biosystems for the production of high-value plant metabolites (the PhytoMetaSyn Project)

Large-scale and ultra-high throughput DNA sequencing provides a means to accelerate the discovery of unique enzymes for the biosynthesis of complex plant metabolites, enabling their production in microbial hosts under controlled conditions. The key deliverables of this project are: (1) a public resource of genomic and metabolomic information for 75 plants producing bioactive natural products,

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Genomics-enhanced forecasting of lignocellulosic feedstock supply for bioenergy

Energy derived from renewable biological materials (i.e. bioenergy) offers a realistic means of reducing our dependence on fossil fuels. This project addresses an issue central to the sustainable production of bioenergy from renewable lignocellulose feedstock under conditions of changing environments. The proposed work seeks to remedy the current lack of accurate tools for reliable prediction

Genomics-enhanced forecasting of lignocellulosic feedstock supply for bioenergy Read More »

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