After ravaging Asia for over a decade, Porcine Epidemic Diarrhea Virus (PEDV) entered USA in April 2013, and Canada in January 2014. Controlling the spread of PEDV by surveillance and biosecurity measures and eliminating the virus from infected farms are industry priorities. This project will investigate genomic and molecular mechanisms associated with PEDV survivorship in neonatal pigs using samples collected from farm outbreaks in Canada and the USA. In addition, the team will develop a test to quantify levels of local immunity that may be present in sows’ milk, and feces and intestines of survivor and dead pigs, as well as used to quantify herd immunity during or after PEDV outbreaks. Deliverables of this proposed project will substantially contribute to the short- and long-term control of PED in North America.