Precision health represents a spectrum of transformative approaches from medicine to public health. Precision medicine aims to harness a wave of discoveries in genomics to deliver the right treatment to the right patient at the right time. Precision public health aims to apply those discoveries to better direct public health interventions. The Alberta Laboratory for Precision Health (ALPH) will develop integrated frameworks to accelerate the development, adoption, and implementation of precision health technologies and interventions to benefit individual/population health and economic development in Alberta. The ALPH program of work will focus on two contexts for precision health: (1) the adoption and implementation of new tests and test-directed treatments, whether developed locally or elsewhere, and (2) support for Albertan developers of precision medicine technologies. The team will address the enablers and barriers for precision medical technologies identified in previous and ongoing practice and research.